The yuri anime genre unfortunately has a reputation for creating relationships between female characters that are incredibly ambiguous. This is a list of anime in which the romantic/sexual relationship between the two girls is very clear (and not one-sided). The girls in question should be major characters and their relationship should be one of if not the biggest driving point(s) of the show. No hentai titles, as adding even one would get the whole list marked nsfw. Some representation on this list is better than others, and I have provided an opinion under each title.
I would like to continue growing this list, so if I am missing one that you think fits the above criteria, please message me! Thank you.
And no, Gushing over Magical girls is not on here. I do not feel comfortable recommending it to anyone.
There will be a part 2 to this once the total goes above 50.